Folklore

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Germline Variant Classification with EU-Hosted AI

Folklore by Helena Bioinformatics is a germline variant classification platform that annotates, classifies and prioritises a whole-genome VCF in under 10 minutes, with an EU-hosted AI assistant that explains every case.

Category:

AI Data

Use Cases:

Data Analysis

AI Knowledge Assistants

Pricing Model:

Freemium

Pricing Snapshot

Billing Frequence:

Monthly / Yearly / Credits

Paid Option From:

€491.67/month billed yearly (€5,900/year); €590 monthly

Last Known Major Update:

2026 (platform v3.39.1)

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At a glance

Updated on AITL:

November 1, 2026

Pros:

Classifies and prioritises a whole-genome VCF in under 10 minutes | Deterministic, traceable ACMG/AMP classification with geneticist sign-off | AI assistant runs on EU-hosted infrastructure with no external AI calls | Covers nuclear, mtDNA, SV/CNV, trio and cohort analysis in one case view | Free plan with 3 credits plus a public MCP server for AI agents

Cons:

Paid plans start at €590 per month, priced for laboratories | Prices are in euros and exclude VAT | API access only on the €1,890 Complete plan or Enterprise | Results are decision support and need validation by a qualified geneticist | Requires genomic data files and specialist knowledge to use

API Available

No public API available

Who It’s Best For

No items found.

Integrates With

No direct integrations listed

No public direct integrations currently listed with Zapier, Make, or Albato.

About the tool

Folklore is a variant interpretation platform for clinical genetics labs, built by Helena Bioinformatics. It takes a VCF from whole-genome or exome sequencing, annotates it against 45 curated databases, applies deterministic ACMG/AMP classification, and prioritises the results with phenotype, screening and family data. A whole genome is ready for review in under 10 minutes, and a geneticist inspects the fired criteria and signs a tiered, traceable report. Eight modules sit in one case view: variant classification, mitochondrial DNA under MMDWG 2020, structural variants and CNVs under Riggs 2020, HPO phenotype matching, clinical screening tiers, cohort analysis, family and trio analysis, and PubMed literature evidence. An AI-native clinical assistant, running on a large language model hosted on EU GPU infrastructure, answers questions about the whole case without sending patient data to external AI services. It explains why criteria were triggered but cannot change classifications. A public MCP server and Chrome extension let ChatGPT, Claude, Grok and Perplexity look up public variants. Folklore is aimed at clinical geneticists, rare-disease and newborn or carrier screening programmes, and genomics researchers. The Free plan includes 3 credits at signup. Individual costs €590 per month, Team €1,240 and Complete €1,890 with API access and FASTQ processing, with two months free on yearly billing. Credits start at €59 per whole-genome analysis and never expire. Prices exclude VAT.

Key Use Cases

Data Analysis

Explore how data analysis tools help teams transform raw data into actionable insights through summaries, pattern detection, and anomaly spotting.

AI Knowledge Assistants

Discover how AI Knowledge Assistants streamline access to information across documents, meetings, and systems, boosting productivity for your team.

API & Developers Readiness

The Folklore REST API (api.helena.bio/folklore/v1) accepts VCF, paired FASTQ, BAM or CRAM and returns a PDF report and structured analysis results. It requires the Complete plan or an approved Enterprise account. A public, read-only MCP server (helena-bioinformatics/folklore-mcp on GitHub) lets AI agents classify public germline variants and search literature. Paid plans from €491.67/month billed yearly or €590 monthly (Individual), excluding VAT.

Automation integrations

Native connectors with Zapier, Make and Albato, checked by AITL.

No direct integrations listed

No public direct integrations currently listed with Zapier, Make, or Albato.

Official channels

Where this tool is active and shares its updates.

LinkedIn YouTube GitHub

No official social channels listed for this tool yet. Use the website link above for the latest news.

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Pricing and plans

Free: €0. 3 credits once at signup, 1 geneticist, individual VCF case analysis, phenotype and screening modules, predefined gene panels and 1 data connection.
Individual: €590/month, or €491.67/month billed yearly (€5,900/year). Unlimited WES and WGS VCF cases, 1 geneticist, family, duo and trio results, custom gene panels, reports and export, 3 data connections and standard support.
Team: €1,240/month, or €1,033.33/month billed yearly (€12,400/year). Up to 5 geneticists, batch upload and processing, shared cases and assignment, collaborative review, 5 data connections and priority support.
Complete: €1,890/month, or €1,575/month billed yearly (€18,900/year). Unlimited VCF and FASTQ cases, up to 10 geneticists, BAM and CRAM input, API access and automation, unlimited data connections and personal onboarding.
Enterprise: custom pricing. More than 10 geneticists, multi-site requirements, integration planning, contracted support and SLA.
Credits: from €59 per credit. 1 credit = 1 WGS VCF or 2 WES VCF analyses; 10 credits €390, 50 credits €1,750, 100 credits €2,900.

Prices exclude VAT. Yearly billing is paid in advance and saves about 17%, the equivalent of two monthly payments. Purchased credits never expire and are shared across your organization; FASTQ processing on Individual and Team is paid with credits. After cancelling, the plan stays active until the end of the paid period, then Free limits apply.

November 1, 2026

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